Faced with many hardships, Jacob exclaimed, “All these things are against me.”
Gen 42:36 And Jacob their father said unto them, Me have ye bereaved of my children: Joseph is not, and Simeon is not, and ye will take Benjamin away: all these things are against me.
In reality, God was orchestrating the troubles that he was experiencing for great good for Jacob and the Israelites (cf. Gen. 50:20).
When we encounter hardship, especially multiple challenges at the same time, or sequentially, we should not respond like Jacob by thinking that everything that is happening is against us. Instead, we must view all that happens to us properly based on what God has told us He is actually doing:
Rom 8:28 And we know that all things work together for good to them that love God, to them who are the called according to his purpose.
With Paul, if you are a Christian, rest confidently in knowing that “all these things” are not against you. Rather, our Father is making them all work together for His glory and our greatest good.